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Of vitamin D, a relationship between low vitamin D status and heart disease, congestive heart failure gene variant affecting vitamin D activation linked. Now, a new study shows that people with high blood pressure,. A gene variant that an enzyme critical normal vitamin D activation are affected twice as often as those without the variant to have congestive heart failure This study, the first indication of a genetic link between vitamin D action and heart disease, says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and an author of the study in the journal Pharmacogenomics. This study showed that a critical enzyme absolutely required for the production of vitamin D, a genetic variation in the development of congestive heart failure is associated, Simpson says. If subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to earlier screening for the most vulnerable and slow progress of the disease. Test would take years. – Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation, Marshfield, Wisconsin examined the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. You searched variants candidate genes candidate genes for their roles in vitamin D regulation and hypertension. A third of the subjects both high blood pressure and heart failure, one-third had high blood pressure about a third were included as healthy controls.

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