Jeffrey Sosman.

We believe that the mix of dabrafenib and trametinib warrants additional evaluation as a potential treatment for metastatic melanoma with BRAF V600 mutations and other cancers with these mutations.. Keith T. Flaherty, M.D., Jeffery R. Infante, M.D., Adil Daud, M.D., Rene Gonzalez, M.D., Richard F. Kefford, M.D., Ph.D., Jeffrey Sosman, M.D., Omid Hamid, M.D., Lynn Schuchter, M.D., Jonathan Cebon, M.D., Ph.D., Nageatte Ibrahim, M.D., Ragini Kudchadkar, M.D., Howard A. Burris, III, M.D., Gerald Falchook, M.D., Alain Algazi, M.D., Karl Lewis, M.D., Georgina V. Long, M.D., Ph.D., Igor Puzanov, M.D., M.S.C.I., Peter Lebowitz, M.D., Ph.D., Ajay Singh, M.D., Shonda Small, M.P.H., Peng Sunlight, Ph.D., Alicia Allred, Ph.D., Daniele Ouellet, Ph.D., Kevin B.When you lose weight, it is likely you are losing visceral fat, which is known to be associated with cardiovascular and other health advantages.’.. Martin R. Cowie, M.D., Holger Woehrle, M.D., Karl Wegscheider, Ph.D., Christiane Angermann, M.D.D., Ph.D., Erland Erdmann, M.D., Patrick Levy, M.D., Ph.D., Anita K. Simonds, M.D., Virend K. Somers, M.D., Ph.D., Faiez Zannad, M.D., Ph.D., and Helmut Teschler, M.D.: Adaptive Servo-Ventilation for Central Rest Apnea in Systolic Center Failure Sleep-disordered breathing is usually common in patients who have heart failure with reduced ejection fraction, with reported prevalence rates of 50 to 75 percent.1 Obstructive sleep apnea takes place more often in sufferers with heart failure than in the general population.2 The prevalence of central rest apnea increases in parallel with increasing severity of heart failure1 and worsening cardiac dysfunction.3 There are a true number of mechanisms where central sleep apnea may be detrimental to cardiac function, including increased sympathetic nervous system activity and intermittent hypoxemia.4-6 Central sleep apnea is an independent risk marker for poor loss of life and prognosis in individuals with heart failure.4,7,8 In the Canadian Continuous Positive Airway Pressure for Sufferers with Central Rest Apnea and Cardiovascular Failure study, patients with heart failure and central sleep apnea were randomly assigned to receive continuous positive airway pressure or simply no CPAP.9 The trial was halted prematurely and didn’t show a beneficial aftereffect of CPAP on morbidity or mortality.10 Adaptive servo-ventilation is usually a non-invasive ventilatory therapy that effectively alleviates central sleep apnea by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure.11,12 The Treatment of Sleep-Disordered Breathing with Predominant Central Rest Apnea by Adaptive Servo Ventilation in Individuals with Heart Failure trial investigated the effects of adding adaptive servo-ventilation to guideline-based treatment on survival and cardiovascular outcomes in sufferers who had heart failure with minimal ejection fraction and predominantly central sleep apnea.