Neither of the parties endorse or recommend any commercial products, services, or equipment.. Acute manic episodes linked to increased edema risk By Lucy Piper, Senior medwireNews Reporter Bipolar disorder patients admitted to hospital with a manic show are at an increased risk for lower limb edema , weighed against their peers with depressive or non-affective psychosis episodes, study findings show. The results suggest a possible causal relationship between feeling and fluid imbalance, says the united team, and a possible role for LLE as a surrogate physical marker for severe manic exacerbation. Experts Eldar Hochman and colleagues assessed the medical records of 2529 sufferers admitted to the center between 2002 and 2012, of whom 1563 got non-affective psychosis, 366 a manic episode, and 600 a depressive show.Based on the upper limits of the self-confidence intervals for the risk estimates, our findings are inconsistent with raises in risk associated with ondansetron greater than 25 percent for preterm delivery, 44 percent for infants who had been small for gestational age at birth, and 82 percent for any major birth defect, among others. A potential way to obtain confounding in observational research of medication effects is that the condition for which the procedure is used may itself be associated with the study outcome .